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 Formulary Chapter 1: Gastro-intestinal system - Full Chapter
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01.06.07  Expand sub section  Other drugs used in constipation
Linaclotide (Constella▼®)
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Formulary
Amber
  • For moderate to severe IBS-Constipation.
  • For patients who have not responded adequately to or cannot tolerate all other suitable treatment options BUT BEFORE other agents with higher costs.
  • Supported by a RICaD
     
  •    
    Lubiprostone  (Amitiza▼ ®)
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    Formulary
    Amber
    Restricted to gastroenterology consultant initiation in line with NICE TA 318.

    GPs may continue the prescribing when a review after 2 weeks therapy demonstrates benefit. Supported by RICaD, see link below. 
    Link  NICE TA318: Lubiprostone for treating chronic idiopathic constipation
    Link  RICaD: Lubiprostone in chronic idiopathic constipation in adults.
       
    Prucalopride (Resolor ®)
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    Formulary
    Amber

    Available for use in men and women for chronic constipation.

    Supported by a RICaD

    Use in men approved following review in March 2018

     
    Link  RICaD: Prucalopride in chronic constipation
    Link  NICE TA211: Constipation (women) - prucalopride
       
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    Key
    note Notes
    Section Title Section Title (top level)
    Section Title Section Title (sub level)
    First Choice Item First Choice item
    Non Formulary Item Non Formulary section
    Restricted Drug
    Restricted Drug
    Unlicensed Drug
    Unlicensed
    Track Changes
    Display tracking information
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    Link to adult BNF
    click to search medicines.org.uk
    Link to children's BNF
    click to search medicines.org.uk
    Link to SPCs
    Cytotoxic Drug
    Cytotoxic Drug
    CD
    Controlled Drug
    High Cost Medicine
    High Cost Medicine
    Cancer Drugs Fund
    Cancer Drugs Fund
    NHSE
    NHS England
    Homecare
    Homecare
    CCG
    CCG

    Traffic Light Status Information

    Status Description

    Green

    Medicines which are suitable for initiation and maintenance prescribing by primary and secondary care clinicians. These medicines should be initiated and prescribed within their licensed indications.  

    Amber

    Initiation and maintenance of prescribing by Specialists and transfer to Primary Care prescribing when appropriate, or initiation and maintenance of prescribing in Primary Care following recommendation from a Specialist.

    Some amber medicines require agreement with the local (internal) medicines committee prior to initiation; others may require a framework to support safe transfer and maintenance of care such as a RICaD or ESCA. The Formulary will be annotated to reflect these requirements.   

    Red

    Medicines for initiation and maintenance prescribing by Specialists only  

    Black

    Non-formulary medicines- medicines not recommended for routine primary care prescribing.  

    Grey

    Positive NICE TA and /or awaiting local clarification on place in therapy ; Please contact your Medicines Optimisation team for more information.  

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