For topical treatment of inflammatory lesions of rosacea (papulopustular) in adults.
Alternative treatment option to metronidazole 0.75% cream/gel (see section 220.127.116.11) or azelaic acid 15% gel (see section 13.6.1)
Brimonidine tartrate gel (Mirvaso®) (3mg/g)
For facial erythema in rosacea
Non Formulary Items
Abrasive Agents (Brasivol®)
Benzoyl Peroxide with antimcrobials (Quinoderm®)
Erythromycin 40mg with Zinc Acetate 12mg/mL (Zineryt®)
Isotretinoin 0.05% gel
Avoid in pregnancy
Discontinued. Manufacturer confirmed in April 2017 that production has ceased and that no new batches will be manufactured or shipped.
Isotretinoin with antibacterial (Isotrexin®)
Salicylic Acid (Acnisal®)
Salicylic Acid 3% w/w, Sulphur 3% w/w in Aqueous Cream
Salicylic Acid in White Soft Paraffin
Tretinoin with antibacterial (Aknemycin® Plus)
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Prescribing in children
The APC notes that the informed use of unlicensed medicines or of licensed medicines for unlicensed applications (‘off-label’ use) is often necessary in paediatric practice.
The APC advises GPs to consider specialist prescribing recommendations for Green and Amber medicines that are not subject to ESCAs or RICaDs in combination with the information provided in the BNFC which goes beyond that of marketing authorisations. The BNFC has been designed for rapid reference and the information presented has been carefully selected to aid decisions on prescribing.
Medicines which are suitable for initiation and maintenance prescribing by primary and secondary care clinicians. These medicines should be initiated and prescribed within their licensed indications.
Initiation and maintenance of prescribing by Specialists and transfer to Primary Care prescribing when appropriate, or initiation and maintenance of prescribing in Primary Care following recommendation from a Specialist.
Some amber medicines require agreement with the local (internal) medicines committee prior to initiation; others may require a framework to support safe transfer and maintenance of care such as a RICaD or ESCA. The Formulary will be annotated to reflect these requirements.
Medicines for initiation and maintenance prescribing by Specialists only
Non-formulary medicines- medicines not recommended for routine primary care prescribing.
Positive NICE TA and /or awaiting local clarification on place in therapy ; Please contact your Medicines Optimisation team for more information.