netFormulary NHS
Birmingham, Sandwell, Solihull and environs APC Formulary
Maintained by Midlands and Lancashire Commissioning Support Unit
 Search
 Formulary Chapter 5: Infections - Full Chapter
Notes:
Broad-spectrum antibiotics SHOULD NOT be used outside of the Primary Care Antimicrobial Guidelines, unless recommended by a specialist, in line with antimicrobial stewardship.
Please be aware that all GREEN drugs are only green if used in line with antimicrobial guidelines. 
Chapter Links...
 Details...
05.01  Antibacterial drugs
05.01  Table 1. Summary of antibacterial therapy
05.01  Table 2. Summary of antibacterial prophylaxis
05.01.01  Penicillins
05.01.01.01  Benzylpenicillin and phenoxymethylpenicillin to top
Benzylpenicillin
View adult BNF View SPC online View childrens BNF
Formulary
Green
 
Link  Primary care antimicrobial guidelines 2017
   
Benzylpenicillin Benzathine
View adult BNF View SPC online View childrens BNF
Restricted Drug Restricted
Red
  • Only GUM STD services 
  •    
    Phenoxymethylpenicillin (oral presentations)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Green
     
    Link  Primary care antimicrobial guidelines 2017
       
    Procaine Penicillin G Injection
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    05.01.01.02  Penicillinase-resistant penicillins
    Flucloxacillin (oral presentations)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Green

    As per antimicrobial guidelines

     
       
    Flucloxacillin (injection)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red

     
    Link  UKMI Q&A: Can 2g flucloxacillin be given as a slow IV
       
    Temocillin (Negaban®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    05.01.01.03  Broad-spectrum penicillins
    Amoxicillin (oral presentations)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Green
     
    Link  Primary care antimirobial guidelines 2017
       
    Amoxicillin (injection)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Co-Amoxiclav (oral presentations)
    View adult BNF View SPC online View childrens BNF
    Formulary

    Green Traffic Light Only when used in line with Antimicrobial guidelines 
     
    Amber Traffic Light When used outside Antimicrobial guidelines, on Specialist recommendation.

     
    Link  Primary care antimicrobial guidelines 2017
       
    Co-Amoxiclav (injection)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    05.01.01.04  Antipseudomonal penicillins
    Piperacillin and Tazobactam
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Ticarcillin with clavulanic acid (Timentin®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    05.01.01.05  Mecillinams
    Pivmecillinam Hydrochloride
    View adult BNF View SPC online View childrens BNF
    Formulary
    Amber
    • In line with Antimicrobial Guidelines
    • Only on microbiology advice
     
    Link  Primary care antimicrobial guidelines 2017
       
    05.01.02  Cephalosporins, carbapenems and other beta-lactums to top
    05.01.02  Cephalosporins
    05.01.02  Other beta-lactam antibiotics
    05.01.02.01  Cephalosporins
    Cefalexin (oral presentations)
    View adult BNF View SPC online View childrens BNF
    Formulary

    Green Traffic Light Only when used in line with Antimicrobial guidelines

    Amber Traffic Light When used outside Antimicrobial guidelines, on Specialist recommendation.

     
    Link  Primary care antimicrobial guidelines 2017
       
    Cefotaxime (injection)
    View adult BNF View SPC online View childrens BNF
    Formulary

    Green Traffic Light Only when used in line with Antimicrobial guidelines

    Amber Traffic Light When used outside Antimicrobial guidelines, on Specialist recommendation.

     
    Link  Primary care antimicrobial guidelines 2017
       
    Ceftazidime
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Ceftriaxone
    View adult BNF View SPC online View childrens BNF
    Restricted Drug Restricted
    Red
     
       
    Cefuroxime
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    05.01.02.02  Carbapenems
    Ertapenem
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Imipenem with cilastatin (Primaxin®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Meropenem
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    05.01.02.03  Other beta-lactums antibiotics to top
    Aztreonam
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    05.01.03  Tetracyclines
    Demeclocycline (capsules)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
  • See Chapter 6 for non-infection indications 
  •    
    Doxycycline (oral)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Green
     
    Link  Primary care antimicrobial guidelines 2017
       
    Doxycycline (injection)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Minocycline
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Oxytetracycline
    View adult BNF View SPC online View childrens BNF
    Formulary
    Green
     
       
    Tetracycline
    View adult BNF View SPC online View childrens BNF
    Formulary
    Green
  • For H. pylori eradication 
  •    
    05.01.03  Tigecycline
    Tigecycline
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    05.01.04  Aminoglycosides
    Amikacin
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Gentamicin
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Neomycin Sulphate
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Tobramycin
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
  • Injection
  • Nebuliser solution- See Chapter 3 for respiratory specific indications 
  •    
    Tobramycin (Bramitob®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Tobramycin inhaler (TOBI Podhaler®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
    Link  NICE TA276: Cystic fibrosis (pseudomonas lung infection) - colistimethate sodium and tobramycin
       
    05.01.05  Macrolides
    Azithromycin
    View adult BNF View SPC online View childrens BNF
    Formulary


    Green Traffic Light  Tablets/ suspension. When used in line with Primary care antimicrobial guidelines


    Amber Traffic Light  Tablets only. For COPD or bronchiectasis patients who have ≥3 exacerbations per year. Off-label use. Supported by RICaD and Guidelines on Respiratory use of long term azithromycin in adults

    • Do not prescribe azithromycin as stand-alone medication for the indication of gonorrhoea. Refer to GUM clinic for IM ceftriaxone as per current UK guidelines.
     
    Link  Chief Medical Officer letter to General Practitioners (December 2015)
       
    Azithromycin
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    • Do not prescribe azithromycin as stand-alone medication for the indication of gonorrhoea. Refer to GUM clinic for IM ceftriaxone as per current UK guidelines.
     
    Link  Chief Medical Officer letter to General Practitioners (December 2015)
       
    Clarithromycin (oral presentations)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Green
     
    Link  Primary care antimicrobial guidelines 2017
       
    Clarithromycin (injection)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Erythromycin (tablets)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Green
     
    Link  Primary care antimicrobial guidelines 2017
    Link  Meds Q&A: Is there an interaction between erythromycin and statins?
       
    Erythromycin Ethyl succinate (oral suspension)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Green
     
       
    Erythromycin Lactobionate (Injection)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    05.01.06  Clindamycin to top
    Clindamycin (Capsules)
    View adult BNF View SPC online View childrens BNF
    Formulary

    Green Traffic Light Only when used in line with Antimicrobial guidelines

    Amber Traffic Light When used outside Antimicrobial guidelines, on Specialist recommendation.

     
       
    Clindamycin 300mg/2mL Injection
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    05.01.07  Some other antibacterials
    Nitazoxanide
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red

    Hospital use only

     
       
    Dalbavancin
    View adult BNF View SPC online View childrens BNF
    Restricted Drug Restricted
    Red
     
       
    05.01.07  Chloramphenicol
    Chloramphenicol (injection)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    05.01.07  Fosfomycin
    05.01.07  Fusidic acid
    05.01.07  Vancomycin and teicoplanin to top
    Teicoplanin (injection)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Vancomycin (capsules)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Amber
  • On recommendation from specialist for severe clostridium difficile 
  •    
    Vancomycin (injection)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    05.01.07  Daptomycin
    Daptomycin (injection)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    05.01.07  Linezolid
    Linezolid (oral formulations)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Amber
  • On advice from microbiologist for MRSA 
  •    
    Linezolid (infusion)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    05.01.07  Quinupristin and dalfopristin
    05.01.07  Polymyxins
    Colistimethate (injection)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Colistimethate for nebulisation
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    • See Chapter 3 for respiratory specific indications
     
       
    Colistimethate inhaler (Colobreathe®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
    Link  NICE TA276: Cystic fibrosis (pseudomonas lung infection) - colistimethate sodium and tobramycin
       
    05.01.07  Rifaximin to top
    Rifaximin
    View adult BNF View SPC online View childrens BNF
    Formulary
    Amber
  • In line with NICE
  • Supported by RICaD, see link below.  
  • Link  NICE TA 337: Rifaximin for preventing episodes of overt hepatic encephalopathy
    Link  RICaD: Rifaximin
       
    05.01.07  Fidaxomicin
    Fidaxomicin
    View adult BNF View SPC online View childrens BNF
    Formulary
    Amber
     
       
    05.01.08  Sulphonamides and trimethoprim
    Co-trimoxazole (oral presentations)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Amber
     
       
    Co-trimoxazole (IV infusion)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
    Link  UKMI Q&A: How to prepare and administer intravenous co-trimoxazole in fluid restricted patients?
       
    Sulfadiazine
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Trimethoprim
    View adult BNF View SPC online View childrens BNF
    Formulary
    Green
     
    Link  Primary care antimicrobial guidelines 2017
       
    05.01.09  Antituberculosis drugs
    Capreomycin
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Cycloserine
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Ethambutol
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red

    Ethambutol liquid 400mg in 5ml (unlicensed)

     
    Link  RMOC Recommendation: Standardising strengths of high risk, unlicensed oral liquids formulations for anti-TB medicines
       
    Isoniazid
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    • RED status also applies to post renal transplant use ( for prophylaxis of TB in renal transplant patients)

    Isoniazid liquid 50mg in 5ml (unlicensed)

     
    Link  RMOC Recommendation: Standardising strengths of high risk, unlicensed oral liquids formulations for anti-TB medicines
       
    Pyrazinamide
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red

    Pyrazinamide liquid 500mg in 5ml (unlicensed)

     
    Link  RMOC Recommendation: Standardising strengths of high risk, unlicensed oral liquids formulations for anti-TB medicines
       
    Rifabutin
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Rifampicin (infusion)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Rifampicin (oral presentations)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Amber
     
       
    Rifampicin and Isoniazid (Rifinah® 300)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Rifampicin and Isoniazid (Rifinah® 150)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Rifampicin and Isoniazid and Pyrazinamide (Rifater®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Rifampicin with ethambutol, isoniazid and pyrazinamide (Voractiv®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Streptomycin Sulphate
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    05.01.10  Antileprotic drugs
    Dapsone
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
  • See Chapter 13 for use in dermatology 
  •    
    05.01.11  Metronidazole and tinidazole to top
    Metronidazole
    View adult BNF View SPC online View childrens BNF
    Formulary
    Green
  • Tablets
  • Suspension ££ 
  •    
    Metronidazole (infusion)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Metronidazole (Suppositories)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Tinidazole
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    05.01.12  Quinolones
    Ciprofloxacin (oral presentations)
    View adult BNF View SPC online View childrens BNF
    Formulary

    Green Traffic Light Only when used in line with Antimicrobial guidelines

    Amber Traffic Light When used outside Antimicrobial guidelines, on Specialist recommendation.

     
    Link  Primary care antimicrobial guidelines 2017
       
    Ciprofloxacin (infusion)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Levofloxacin (infusion)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Levofloxacin (tablets)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Amber
  • For multi resistant organisms, on advice of specialist 
  •    
    Moxifloxacin
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Norfloxacin
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Ofloxacin
    View adult BNF View SPC online View childrens BNF
    Formulary

    Green Traffic Light Only when used in line with Antimicrobial guidelines

    Amber Traffic Light When used outside Antimicrobial guidelines, on Specialist recommendation.

     
    Link  Primary care antimicrobial guidelines 2017
       
    05.01.13  Urinary-tract infections
    Fosfomycin (Capsules)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Amber

    Second line treatment if high risk of resistance. In line with antimicrobial guidelines

     
       
    Fosfomycin (sachets)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Amber
    • Second line treatment if high risk of resistance
    • In line with Antimicrobial Guidelines
     
    Link  Primary care antimicrobial guidelines 2017
       
    Methenamine Hippurate
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Nitrofurantoin
    View adult BNF View SPC online View childrens BNF
    Formulary
    Green
  • Tablets
  • M/R Capsules
     
  • Link  Primary care antimicrobial guidelines 2017
    Link  MHRA alert: Nitrofurantoin now contraindicated in most patients with an estimated glomerular filtration rate (eGFR) of less than 45 ml/min/1.73m2
       
    05.02  Antifungal drugs
    Amphotericin (infusion)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Amphotericin (lipid complex infusion)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Fluconazole
    View adult BNF View SPC online View childrens BNF
    Formulary
    Green
  • Capsules
  • Suspension- For patients with swallowing difficulties only 
  • Link  UKMI Q&A: Can oral fluconazole be used with breastfeeding?
       
    Flucytosine
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Isavuconazole (Cresemba®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Itraconazole
    View adult BNF View SPC online View childrens BNF
    Formulary
    Green
  • Capsules
  • SF liquid ££ 
  •    
    Itraconazole (injection)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Nystatin (oral suspension )
    View adult BNF View SPC online View childrens BNF
    Formulary
    Green
  • Not Sugar free  
  • Link  Primary care antimicrobial guidelines 2017
       
    Posaconazole
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Terbinafine (tablets)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Green
     
       
    Voriconazole
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    05.02  Treatment of fungal infections
    05.02  Drugs used in fungal infections to top
    05.02.01  Triazole antifungals
    05.02.02  Imidazole antifungals
    05.02.03  Polyene antifungals
    05.02.04  Echinocandin antifungals
    Anidulafungin
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Caspofungin
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Micafungin
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    05.02.05  Other antifungals to top
    05.03  Antiviral drugs
    05.03.01  HIV infection
    05.03.01  Nucleoside reverse transcriptase inhibitors
    Abacavir (Ziagen®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Abacavir and Lamivudine (Kivexa®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Didanosine (Videx®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Emtricitabine (Emtriva®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Lamivudine (Epivir®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Lamivudine (Zeffix®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Rilpivirine hydrochloride (Edurant®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Stavudine (Zerit®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Tenofovir 245mg, Efavirenz 600mg and Emtricitabine 200mg (Atripla®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Tenofovir and Emtricitabine (Truvada®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Tenofovir Disproxil (Viread®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
    Link  NICE CG165: Hepatitis B (chronic) - incorporates TA173
    Link  NICE TA173: Hepatitis B (chronic) - tenofovir disoproxil
       
    Zidovudine
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Zidovudine and Lamivudine
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    05.03.01  Protease inhibitors
    Atazanavir (Reyataz®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Darunavir (Prezista®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Fosamprenavir (Telzir®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Lopinavir and Ritonavir (Kaletra®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Ritonavir (Norvir®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Saquinavir (Invirase®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    05.03.01  Non-nucleoside reverse transcriptase inhibitors to top
    Efavirenz (Sustiva®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Etravirine (Intelence®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Nevirapine
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    05.03.01  Other antiretrovirals
    Maraviroc
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Raltegravir (Isentress ®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    05.03.01  Pharmacokinetic enhancers of antiretrovirals
    05.03.02  Herpesvirus infections
    05.03.02.01  Herpes simplex and varicella-zoster infection
    Aciclovir (injection)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Aciclovir (oral )
    View adult BNF View SPC online View childrens BNF
    Formulary
    Green
  • Tablets
  • Dispersible tablets £
  • Suspension ££ 
  •    
    Famciclovir
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Valaciclovir (Tablets)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Green
  • In exceptional cases: second line for shingles if compliance is a problem £££ 
  •    
    05.03.02.02  Cytomegalovirus infection to top
    Foscarnet Sodium (Foscavir®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Ganciclovir (Cymevene®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Letermovir
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    NHS England

    Use in line with NICE

     
    Link  NICETA 591: Letermovir for preventing cytomegalovirus disease after a stem cell transplant
       
    Valganciclovir (Valcyte®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    05.03.03  Viral hepatitis
    Adefovir Dipivoxil (Hepsera®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
    Link  NICE CG165: Hepatitis B (chronic) - incorporates TA96
    Link  NICE TA96: Hepatitis B (chronic) - adefovir dipivoxil and pegylated interferon alpha-2a
       
    Boceprevir (Victrelis®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
    Link  NICE TA253: Hepatitis C (genotype 1) - boceprevir
       
    Entecavir (Baraclude®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
    Link  NICE CG165: Hepatitis B (incorporates TA153)
    Link  NICE TA153: Hepatitis B (chronic) - entecavir
       
    Telaprevir (Incivo®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
    Link  NICE TA252: Hepatitis C (genotype 1) - telaprevir
       
    05.03.03.01  Chronic hepatitis B
    Telbivudine (Sebivo®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
  • NOT RECOMMENDED 
  • Link  NICE TA154: Hepatitis B - telbivudine
       
    05.03.03.02  Chronic hepatitis C
    Daclatasvir (Daklinza®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    High Cost Medicine
    In line with NICE 
    Link  NICE TA364: Daclatasvir for treating chronic hepatitis C
       
    Glecaprevir–pibrentasvirBlack Triangle (Maviret®)
    Formulary
    Red
    High Cost Medicine
    NHS England

    In line with NICE

     

     
    Link  NICE TA 499: Glecaprevir–pibrentasvir for treating chronic hepatitis C
       
    Ledipasvir- sofosbuvir (Harvoni®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    High Cost Medicine
    In line with NICE 
    Link  NICE TA363: Ledipasvir-sofosbuvir for treating chronic hepatitis C
       
    Ombitasvir-paritaprevir-ritonavir (Viekirax®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    High Cost Medicine
    In line with NICE 
    Link  NICE TA365: Ombitasvir-paritaprevir-ritonavir for treating chronic hepatitis C
       
    Sofosbuvir-velpatasvir-voxilaprevir
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
    NHS England

    Hospital only - NHSE commissioned

    In line with NICE

     
    Link  NICE TA507: Sofosbuvir–velpatasvir–voxilaprevir for treating chronic hepatitis C
       
    05.03.04  Influenza
    Oseltamivir (Tamiflu®)
    View adult BNF View SPC online View childrens BNF
    First Choice
    Green

     

    PHE guidance on use of antiviral agents for the treatment and prophylaxis of seasonal influenza

     
    Zanamivir inhalation (Relenza®)
    View adult BNF View SPC online View childrens BNF
    Second Choice
    Green
     
    Link  Primary care antimicrobial guidelines 2017
    Link  UKMI Q&A: Can mothers breastfeed after treatment for influenza?
       
    05.03.05  Respiratory syncytial virus to top
    Palivizumab (Synagis®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Ribavirin
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
  • Capsules
  • Tablets
  • Inhalation 
  • Link  NICE TA75: Hepatitis C - pegylated interferons, ribavirin and alfa interferon
    Link  NICE TA106: Hepatitis C - peginterferon alfa and ribavirin
    Link  NICE TA200: Hepatitis C - peginterferon alfa and ribavirin
    Link  NICE TA300: Hepatitis C (children and young people) - peginterferon alfa and ribavirin
       
    05.04  Antiprotozoal drugs
    05.04.01  Antimalarials
    05.04.01  Treatment of malaria
    05.04.01  Falciparum malaria (treatment)
    Artesunate
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red

    Injection

     
       
    05.04.01  Benign malarias (treatment) to top
    05.04.01  Prophylaxis against malaria
    05.04.01  Specific recommendations
    05.04.01  Artemether with lumefabtrine
    Artemether with lumefantrine (Riamet®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    05.04.01  Chloroquine
    05.04.01  Mefloquine to top
    Mefloquine (Lariam®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Green
  • Private prescription in Primary Care  
  •    
    05.04.01  Primaquine
    Primaquine
    View adult BNF View SPC online View childrens BNF
    Formulary
    Green
  • Private prescription in Primary Care  
  •    
    05.04.01  Proguanil
    Proguanil Hydrochloride
    View adult BNF View SPC online View childrens BNF
    Formulary
    Green
  • Private prescription in Primary Care  
  •    
    Proguanil Hydrochloride with Atovaquone
    View adult BNF View SPC online View childrens BNF
    Formulary
    Green
  • Private prescription in Primary Care  
  •    
    05.04.01  Pyrimethamine
    Pyrimethamine (Darprim®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    05.04.01  Quinine
    Quinine dihydrochloride
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
  • Injection 
  •    
    Quinine sulphate
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
  • Tablets 
  •    
    05.04.01  Tetracyclines to top
    05.04.02  Amoebicides
    Diloxanide Furoate (Diloxanide®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    05.04.03  Trichomonacides
    05.04.04  Antigiardial drugs
    Mepacrine Hydrochloride
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    05.04.05  Leishmaniacides
    Paromomycin  (suspension)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
  • Unlicensed 
  •    
    05.04.06  Trypanocides to top
    05.04.07  Drugs for toxoplasmosis
    Spiramycin
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
  • Unlicensed 
  •    
    05.04.08  Drugs for pneumocystis pneumonia
    Atovaquone
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    Pentamidine Isetionate (Pantacarinat®)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
     
       
    05.04.08  Treatment
    05.04.08  Prophylaxis
    05.05  Anthelmintics to top
    05.05.01  Drugs for threadworms
    Mebendazole
    View adult BNF View SPC online View childrens BNF
    Formulary
    Green
     
       
    05.05.02  Ascaricides
    Levamisole
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
  • Unlicensed 
  •    
    05.05.03  Drugs for tapeworm infections
    05.05.03  Taenicides
    05.05.03  Hydatid disease to top
    05.05.04  Drugs for hookworms
    05.05.05  Schistosomicides
    Praziquantel (tablets)
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
  • UNLICENSED, on specialist advice only 
  •    
    05.05.06  Filaricides
    Ivermectin
    View adult BNF View SPC online View childrens BNF
    Formulary
    Amber
  • Unlicensed, for crusted scabies, on specialist advice 
  •    
    05.05.07  Drugs for cutaneous larva migrans
    05.05.08  Drugs for strongyloidiasis to top
    Albendazole
    View adult BNF View SPC online View childrens BNF
    Formulary
    Red
  • UNLICENSED 
  •    
     ....
     Non Formulary Items
    Abacavir and Lamivudine and Zidovudine  (Trizivir®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Aciclovir lauriad  (Sitavig)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Amantadine Hydrochloride

    View adult BNF View SPC online View childrens BNF
    Non Formulary
    Black

    Non formulary for Influenza

     
    Amantadine Hydrochloride  (Symmetrel®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
    Black

    Non formulary for influenza

     
    Ampicillin

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Ampicillin  (Penbritin®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Amprenavir  (Agenerase®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Aztreonam nebuliser solution  (Cayston®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Cefaclor

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Cefadroxil

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Cefixime  (Suprax®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
    Black
     
    Cefpodoxime

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Cefradine

    View adult BNF View SPC online View childrens BNF
    Non Formulary
    Black
     
    Ceftaroline  (Zinforo®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Chloroquine

    View adult BNF View SPC online View childrens BNF
    Non Formulary
    Green
    • Private prescription in Primary Care
     
    Chloroquine  (Avloclor®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Chloroquine  (Malarivon®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Chloroquine  (Nivaquine®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Chloroquine  (Paludrine® Avloclor)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Cidofovir  (Vistide®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Clofazimine

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Cobicistat  (Tybost®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Co-Fluampicil

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Co-Fluampicil  (Magnapen®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Collatamp EG Sponge

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Doxycycline  (Efracea® MR)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Emtricitabine 200mg, Rilpivirine 25mg and Tenofovir 245mg  (Eviplera®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Enfuvirtide  (Fuzeon®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Fusidic acid  (suspension)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
    Black
  • May be prescribed following approval by individual hospital Medicines Management Committees for specific patients for second line MRSA decolonisation
  •  
    Griseofulvin

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Griseofulvin  (Fulsovin®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Indinavir  (Crixivan®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Inosine Pranobex  (Imunovir®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Ketoconazole  (oral)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
    Link  MHRA alert: Risk of hepatotoxicity with oral ketoconazole
     
    Lymecycline

    View adult BNF View SPC online View childrens BNF
    Non Formulary

    Non-formulary July 2019

     
    Nalidixic Acid  (Uriben®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Netilmicin  (Netillin®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Niclosamide

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Piperazine

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Piperazine

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Proguanil Hydrochloride  (Paludrine®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Proguanil Hydrochloride with Atovaquone  (Malarone® Raediatric)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Pyrimethamine and Dapsone

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Pyrimethamine with Sulfadoxine  (Fansidar®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Quinine Bisulphate

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Quinupristin and dalfopristin  (Synercid®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Rifampicin and Isoniazid  (Rimactazid® 300)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Sodium fusidate  (tablets)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
    Black
  • May be prescribed following approval by individual hospital Medicines Management Committees for specific patients for second line MRSA decolonisation
  •  
    Sodium Stibogluconate  (Pentostam®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Sulfadiazine

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Telithromycin  (Ketek®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Tenofovir, cobicistat, elvitegravir & emtricitabine  (Stribild®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    test Chronic hepatitis C

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Thalidomide

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    TIABENDAZOLE 500mg tabs

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Tinidazole

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Tipranavir  (Aptivus®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
     
    Zanamivir Injection

    View adult BNF View SPC online View childrens BNF
    Non Formulary
    Link  UKMI Q&A: Can zanamivir be given to patients with renal impairment or patients on renal replacement therapies?
     
      
    Key
    note Notes
    Section Title Section Title (top level)
    Section Title Section Title (sub level)
    First Choice Item First Choice item
    Non Formulary Item Non Formulary section
    Restricted Drug
    Restricted Drug
    Unlicensed Drug
    Unlicensed
    Track Changes
    Display tracking information
    click to search medicines.org.uk
    Link to adult BNF
    click to search medicines.org.uk
    Link to children's BNF
    click to search medicines.org.uk
    Link to SPCs
    Cytotoxic Drug
    Cytotoxic Drug
    CD
    Controlled Drug
    High Cost Medicine
    High Cost Medicine
    Cancer Drugs Fund
    Cancer Drugs Fund
    NHSE
    NHS England
    Homecare
    Homecare
    CCG
    CCG

    Traffic Light Status Information

    Status Description

    Prescribing in children

    The APC notes that the informed use of unlicensed medicines or of licensed medicines for unlicensed applications (‘off-label’ use) is often necessary in paediatric practice.

    The APC advises GPs to consider specialist prescribing recommendations for Green and Amber medicines that are not subject to ESCAs or RICaDs in combination with the information provided in the BNFC which goes beyond that of marketing authorisations. The BNFC has been designed for rapid reference and the information presented has been carefully selected to aid decisions on prescribing.

      

    Green

    Medicines which are suitable for initiation and maintenance prescribing by primary and secondary care clinicians. These medicines should be initiated and prescribed within their licensed indications.  

    Amber

    Initiation and maintenance of prescribing by Specialists and transfer to Primary Care prescribing when appropriate, or initiation and maintenance of prescribing in Primary Care following recommendation from a Specialist.

    Some amber medicines require agreement with the local (internal) medicines committee prior to initiation; others may require a framework to support safe transfer and maintenance of care such as a RICaD or ESCA. The Formulary will be annotated to reflect these requirements.   

    Red

    Medicines for initiation and maintenance prescribing by Specialists only  

    Black

    Non-formulary medicines- medicines not recommended for routine primary care prescribing.  

    Grey

    Positive NICE TA and /or awaiting local clarification on place in therapy ; Please contact your Medicines Optimisation team for more information.  

    netFormulary